Endocrine Abstracts

Background: Thyroid hormones (THs) stimulate hepatic de-novo lipid biosynthesis but also lipolysis and beta-oxidation. Similarly, they simultaneously enhance cholesterol uptake, biosynthesis, and degradation. Thyroid hormone receptor beta (THRβ) is the main hepatic thyroid hormone receptor. Mammals have developed a circadian timekeeping system that controls physiological processes to adapt to time-of-day.HypothesisWe hypothesized that TH effects are subject to circadian r...